I wish you well and pray for a quick recovery. When I tell you I had HORRIBLE reactions I mean to the extent that if I did not have such a wonderful, supportive family I do not feel I would be here today. I chose not to go the warfarin direction for several reasons 1) having to go constantly for blood test to check my INR 2) by the time this would have been an option I was so focused on just getting this over with and pray all the side effects would go away once the medication stopped 3) the chance that after all the other medicine I tried and they failed to bring much relief the fear that I would go through a change to warfarin and the same side effects would persist or possibly be worse.īe very thankful that you have had a good experience with the oral anticoagulnt. The last option would have been warfarin. I still had very bad reactions to the shot also, however I was at least able to function to some degree which was better than nothing. The third option that I was given was to do the shot, 90mg once a day for 3 months. The oral anticoagulnts that I was given after being discharged from the hospital both caused HORRIBLE reactions. Why would anyone agree to give themselves painful shots twice a day for six months when they can just take the pill? (Xarelto) (I have researched it and see no medical advantage of Lovenox vs Xarelto.) It sure is easier and less painful to take a small pill and I see no bad reactions to Xarelto. I could not wait until the five days ended so I could move to Xarelto (the pill). It caused bruises all over my stomach area that are slow to heal. (I was given very detailed advice on how to give myself the shot and researched it further online.) Giving myself a Lovenox shot was very difficult to do it right and very painful. I followed the second doctors' advice and gave myself the Lovenox shots in the stomach for the 5 days. Another doctor said I should do the Lovenox for five days then go with the pill Xarelto. The doctor said most of his patients gave themselves a shot using Lovenox twice a day for up to six months. As stated above, having an actual antidote for patients will help ease doctors' concerns about patients suffering a bleed, and should lead to fewer lawsuits in the future.When I got out of the hospital and started my recovery from a submassive pulmonary embolism, I was given the option of taking a blood thinner in a pill form (Xarelto) or giving myself a shot using a large needle (Lovenox). Considering Xarelto works the same way as Eliquis and a Phase II study involving Xarelto was positive, it is likely that the trial results will be positive. While Portola's Andexanet alfa hasn't completed a Phase III trial involving Xarelto, it should be completed soon. Like Eliquis, Xarelto is a Factor Xa inhibitor. While Eliquis only had $171 million in sales, Xarelto pulled in $361 million in the second quarter. This will allow the drug reps for Eliquis to combat its main weakness. Portola's Phase III study used Eliquis to prove that Andexanet alfa is effective at reversing a Factor Xa inhibitor. They are on the rise, though in the second quarter of this year, sales were $171 million, a 50 percent increase from the previous quarter. Eliquis had great data in Phase III trials that led to many analysts projecting great sales for the drug, but so far, sales of the drug have been disappointing. Pfizer and Bristol-Myers Squibb split the revenues equally for Eliquis. However, Eliquis and Xarelto are Factor Xa inhibitors, and will be positively influenced by Portola's new Xa antidote.Įliquis was the last of the three new anticoagulants to make it to the market. ![]() Since Pradaxa is a direct thrombin inhibitor, Portola's Xa antidote won't work for it, so Boehringer Ingelheim is working on its own antidote. To combat this problem, Portola ( PTLA) developed a new called Andexanet alfa, which reverses the effects of Factor Xa inhibitors. ![]() None of the three currently have an approved antidote for a patient experiencing a bleed or needing emergency surgery. While these drugs are more convenient and have less interactions then Coumadin, they had one huge shortcoming. Finally, Pfizer ( PFE) and Bristol-Myers Squibb ( BMY) teamed up to release Eliquis. Then came Xarelto by Johnson & Johnson ( JNJ). First released was Pradaxa, a direct thrombin inhibitor by Boehringer Ingelheim. A few years ago, three new-generation anticoagulants were released in an attempt to improve upon and replace Coumadin.
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